Are the pharmacokinetics for Citalopram different in elderly patients?
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Yes. The pharmacokinetics of citalopram have been studied in elderly patients (aged 73-90) (ref.1). Following administration of citalopram 20 mg once daily, steady-state plasma concentrations in these patients were higher than those seen in younger patients and healthy volunteers. The mean plasma half-life in the elderly (54 hours) was no longer than that in healthy young volunteers (35 hours). On the basis of these findings, a maximum daily dose of 40 mg is recommended for patients over 65 years of age.
References:
1. Overø et al. 1985